Description

p-Tolyl Phosphorodichloridate is a key organophosphorus intermediate used in the synthesis of more complex phosphate esters and derivatives. Its high reactivity as a phosphorylating agent makes it valuable for creating tailored molecules with specific functional properties. This compound is primarily utilized by research chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of nucleotide analogs, prodrugs, and other bioactive phosphate-containing molecules.
• Agrochemical Synthesis: Used in the production of organophosphate insecticides, herbicides, and plant growth regulators.
• Ligand and Catalyst Preparation: Serves as a precursor for phosphite and phosphoramidite ligands used in asymmetric catalysis and transition metal complexes.
• Polymer Modification: Employed to introduce phosphate groups into polymer backbones to alter flame retardancy, adhesion, or compatibility.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D focused on new organophosphorus chemistry and material science.
• Flame Retardant Synthon: Used to synthesize specialized phosphate esters that function as effective flame retardant additives.

Basic Information

Product Name	p-Tolyl Phosphorodichloridate
CAS No.	878-17-1
Molecular Formula	C7H7Cl2O3P
Molecular Weight	241.01 g/mol
Synonyms	Phosphorodichloridic Acid, 4-Methylphenyl Ester; 4-Methylphenyl Phosphorodichloridate; p-Cresyl Phosphorodichloridate; p-Tolyl Dichlorophosphate; Dichloro(p-tolyloxy)phosphine Oxide; O-(4-Methylphenyl) Phosphorodichloridate; Phosphorodichloridous Acid, p-Tolyl Ester
EINECS	Contact for details

Quality Control

Our p-Tolyl Phosphorodichloridate is manufactured under strict process controls to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes rigorous analytical testing, including chromatography and spectroscopic methods, to verify identity and assay. Certificates of Analysis (COA) detailing purity and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.