Description

4-Trifluoromethylphthalic Acid is a high-value, multi-functional aromatic acid derivative characterized by its trifluoromethyl group, which imparts unique electronic and steric properties. This compound is a critical pharmaceutical intermediate and a versatile building block in advanced organic synthesis, enabling the development of novel active ingredients and functional materials. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and liquid crystal industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a building block for developing advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal Materials: Used in the production of fluorinated liquid crystals for high-performance displays (LCDs), where it modifies dielectric anisotropy and improves thermal stability.
• Polymer Modification: Incorporated into polymer backbones to create specialty polyimides and polyesters with enhanced thermal resistance, chemical stability, and optical properties.
• Organic Synthesis Building Block: Employed in metal-catalyzed cross-coupling reactions and as a precursor for heterocyclic compounds like quinazolines and phthalimides.
• Coordination Chemistry: Acts as a chelating ligand for metal-organic frameworks (MOFs) and catalysts due to its two carboxylic acid groups.

Basic Information

Product Name	4-Trifluoromethylphthalic Acid
CAS No.	835-58-5
Molecular Formula	C9H5F3O4
Molecular Weight	234.13 g/mol
Synonyms	4-(Trifluoromethyl)phthalic Acid; 1,2-Benzenedicarboxylic Acid, 4-(Trifluoromethyl)-; 4-Carboxy-2-(trifluoromethyl)benzoic Acid; Phthalic Acid, 4-Trifluoromethyl-; α,α,α-Trifluoro-p-phthalic Acid; 4-TFMPhA; 4-TFMPA; TFMPhA
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethylphthalic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting key parameters such as assay, impurity profile, and moisture content. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, and we support customer audits and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Heavy Metals (as Pb)	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Single impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.