Description

Ethanone, 2-Hydroxy-2-(4-Methylphenyl)-1-Phenyl-, (2S)- (9Ci) is a chiral α-hydroxy ketone compound, a valuable building block in asymmetric synthesis. Its defined stereochemistry at the 2-position makes it a critical intermediate for producing high-value, optically active pharmaceuticals and fine chemicals. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for developing novel active ingredients and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Asymmetric Catalysis: Used as a precursor or ligand in the development of chiral catalysts for enantioselective reactions.
• Agrochemical Synthesis: Serves as an intermediate in the production of chiral pesticides and herbicides, where specific stereochemistry can enhance efficacy and reduce environmental impact.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring precise stereochemical control.
• Academic & Industrial Research: A valuable tool for methodological development in organic synthesis and stereochemistry studies within R&D laboratories.

Basic Information

Product Name	Ethanone, 2-Hydroxy-2-(4-Methylphenyl)-1-Phenyl-, (2S)- (9Ci)
CAS No.	799279-10-0
Molecular Formula	C15H14O2
Molecular Weight	226.27 g/mol
Synonyms	(S)-2-Hydroxy-2-(4-methylphenyl)-1-phenylethanone; (S)-2-Hydroxy-2-p-tolyl-1-phenylethanone; (S)-Benzoin p-tolyl ether; (S)-α-Hydroxy-p-methylbenzhydryl phenyl ketone; (2S)-2-Hydroxy-2-(4-methylphenyl)-1-phenylethanone; L-Selectride® reduction product analog; Chiral α-hydroxy ketone derivative
EINECS	Contact for details

Quality Control

We maintain a stringent quality management system to ensure batch-to-batch consistency and high purity for research and production use. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with enantiomeric excess (ee) tailored to customer requirements. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing parameters such as assay, chiral purity, identity (IR, NMR), and residual solvent content. Specifications can be aligned with cGMP and ICH Q7 guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep away from strong acids and incompatible materials. Due to its sensitivity to oxidation, containers should be sealed immediately after use to minimize exposure to air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee (Standard, customizable)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.