Description

(S)-2-(Benzylamino)-3-((tert-Butyldimethylsilyl)Oxy)Propan-1-Ol CAS NO 794518-59-5 is a high-value, chiral protected amino alcohol intermediate featuring a tert-butyldimethylsilyl (TBDMS) ether group. This compound is critical for its role in asymmetric synthesis, where it serves as a key building block for constructing complex molecules with precise stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), fine chemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce high enantioselectivity.
• Peptidomimetics & Bioactive Molecule Construction: Used to introduce chiral amino alcohol motifs into peptide backbones and other bioactive scaffolds.
• Natural Product Synthesis: Serves as a building block in the total synthesis of complex natural products requiring specific stereocenters.
• Organometallic Catalyst Development: Acts as a precursor for nitrogen-oxygen (N,O) chelating ligands used in transition metal catalysis.
• Material Science Research: Investigated for incorporation into chiral polymers or frameworks with potential optical or catalytic properties.

Basic Information

Item	Detail
Product Name	(S)-2-(Benzylamino)-3-((tert-Butyldimethylsilyl)Oxy)Propan-1-Ol
CAS No.	794518-59-5
Molecular Formula	C16H29NO2Si
Molecular Weight	295.50 g/mol
Synonyms	(S)-2-(Benzylamino)-3-((tert-butyldimethylsilyl)oxy)-1-propanol; (S)-2-(Benzylamino)-3-(tert-butyldimethylsiloxy)propan-1-ol; (S)-3-[(tert-Butyldimethylsilyl)oxy]-2-(benzylamino)-1-propanol; N-Benzyl-O-(tert-butyldimethylsilyl)-L-serinol; TBDMS-protected L-serinol benzyl ether; (S)-1-(Benzylamino)-3-((tert-butyldimethylsilyl)oxy)propan-2-ol (tautomer); Bn-TBDMS-Serinol
EINECS	Contact for details

Quality Control

Every batch of (S)-2-(Benzylamino)-3-((tert-Butyldimethylsilyl)Oxy)Propan-1-Ol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and chiral integrity, meeting the exacting standards required for pharmaceutical R&D and fine chemical synthesis. A Certificate of Analysis (COA) detailing specifications such as chiral purity (enantiomeric excess), chemical purity (by HPLC), and residual solvents is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.