Description

(2-Chloro-5-Iodophenyl)Methanamine Hydrochloride is a high-purity, halogenated aromatic amine hydrochloride salt, a crucial building block in advanced organic synthesis. Its value lies in its unique bifunctional halogen substitution pattern, which enables selective cross-coupling and functionalization reactions critical for constructing complex molecular architectures. This intermediate is primarily needed by pharmaceutical R&D and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used as a precursor in the manufacture of advanced herbicides, fungicides, and pesticides, leveraging its halogenated structure.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the creation of organic electronic materials, liquid crystals, and photoactive compounds.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions.
• Custom Synthesis and Contract Manufacturing: A vital building block for custom synthesis houses serving the pharmaceutical and biotechnology industries.

Basic Information

Product Name	(2-Chloro-5-Iodophenyl)Methanamine Hydrochloride
CAS No.	793695-88-2
Molecular Formula	C7H8Cl2IN
Molecular Weight	304.41 g/mol
Synonyms	1-(2-Chloro-5-iodophenyl)methanamine hydrochloride; (2-Chloro-5-iodobenzyl)amine hydrochloride; 2-Chloro-5-iodobenzylamine hydrochloride; 1-(Aminomethyl)-2-chloro-5-iodobenzene hydrochloride; Benzenemethanamine, 2-chloro-5-iodo-, hydrochloride; 2-Chloro-5-iodo-α-toluidine hydrochloride
EINECS	Contact for details

Quality Control

Our (2-Chloro-5-Iodophenyl)Methanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.