Description

(R)-7-Bromo-1,2,3,4-Tetrahydro-Naphthalen-1-Ylamine Hydrochloride CAS NO 789490-65-9 is a high-purity chiral amine hydrochloride salt, serving as a critical building block in advanced organic synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules with precise biological activity. This intermediate is essential for research and development in the pharmaceutical industry, particularly for medicinal chemists developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and cardiovascular drug discovery.
• Asymmetric Synthesis: Used as a starting material or reagent in catalytic asymmetric reactions to introduce the (R)-configured tetralin amine moiety.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore and optimize the pharmacophore of potential drug candidates.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and receptor interactions.
• Agrochemical Synthesis: Potential intermediate for creating chiral compounds with herbicidal or pesticidal activity.
• Academic & Contract Research: Serves as a valuable reagent for universities and CROs (Contract Research Organizations) engaged in synthetic methodology and drug discovery projects.

Basic Information

Product Name	(R)-7-Bromo-1,2,3,4-Tetrahydro-Naphthalen-1-Ylamine Hydrochloride
CAS No.	789490-65-9
Molecular Formula	C10H13BrN·HCl
Molecular Weight	278.58 g/mol
Synonyms	(1R)-7-Bromo-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride; (R)-7-Bromo-1,2,3,4-tetrahydro-1-naphthylamine hydrochloride; (R)-1-Amino-7-bromo-1,2,3,4-tetrahydronaphthalene hydrochloride; 7-Bromo-(1R)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride; (R)-7-Bromo-1,2,3,4-tetrahydro-1-naphthalenamine HCl; (R)-7-Bromo-1,2,3,4-tetrahydro-naphthalen-1-ylamine HCl; 789490-65-9; (R)-7-Br-Tetralin-1-amine hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥97% (HPLC), with enantiomeric excess (ee) specifications available to meet specific project requirements. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Our quality management system supports development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee (typical, other grades available)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.