Description

1H-Imidazole-4-Ethanamine, -α--(Trifluoromethyl)- (9Ci) is a specialized trifluoromethyl-substituted imidazole derivative, a high-value building block prized for its unique physicochemical profile. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceuticals and agrochemicals, where the trifluoromethyl group is known to enhance metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the imidazole and trifluoromethyl motifs.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Investigated for incorporation into advanced polymers and organic electronic materials to modify electronic properties and stability.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific fluorinated heterocycle.

Basic Information

Item	Details
Product Name	1H-Imidazole-4-Ethanamine, -α--(Trifluoromethyl)- (9Ci)
CAS No.	788778-86-9
Molecular Formula	C6H8F3N3
Molecular Weight	179.15 g/mol
Synonyms	α-(Trifluoromethyl)-1H-imidazole-4-ethanamine; 2-(Trifluoromethyl)-2-(1H-imidazol-4-yl)ethanamine; 4-(2-Amino-3,3,3-trifluoropropyl)-1H-imidazole; 2-(1H-Imidazol-4-yl)-3,3,3-trifluoropropan-1-amine; Trifluoromethylimidazole ethylamine derivative; (3,3,3-Trifluoro-2-(1H-imidazol-4-yl)propyl)amine
EINECS	Contact for details

Quality Control

Our 1H-Imidazole-4-Ethanamine, -α--(Trifluoromethyl)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.