Description

1,2-Pyrrolidinedicarboxylic Acid, 4-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, 2-Methyl 1-(Phenylmethyl) Ester, (2R,4R)- is a high-purity, stereochemically defined chiral intermediate of significant importance in advanced pharmaceutical synthesis. Its core value lies in its role as a critical building block for constructing complex molecules, particularly in the development of protease inhibitors and other active pharmaceutical ingredients (APIs). This compound is essential for research institutions and pharmaceutical manufacturers engaged in the synthesis of novel therapeutics, where precise stereochemistry and reliable quality are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly protease inhibitors.
• API Development: Used in research and development for constructing the core scaffolds of new active pharmaceutical ingredients.
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate in stereoselective chemical reactions.
• Peptidomimetics Research: Employed in the design and synthesis of peptide-like molecules with enhanced stability and bioavailability.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of clinical trial materials and commercial APIs.
• Academic & Industrial R&D: Utilized in chemical research laboratories for methodological development and exploring new synthetic pathways.

Basic Information

Product Name	1,2-Pyrrolidinedicarboxylic Acid, 4-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, 2-Methyl 1-(Phenylmethyl) Ester, (2R,4R)-
CAS No.	787615-48-9
Molecular Formula	C19H25NO6
Molecular Weight	363.41 g/mol
Synonyms	(2R,4R)-4-[(tert-Butoxycarbonyl)amino]-2-methyl-1,2-pyrrolidinedicarboxylic acid 1-benzyl ester 2-methyl ester; (2R,4R)-1-Benzyl 2-methyl 4-[(tert-butoxycarbonyl)amino]-2-methylpyrrolidine-1,2-dicarboxylate; Boc-4-amino-(2R,4R)-2-methylproline benzyl ester methyl ester; (2R,4R)-Boc-Amp(OBzl)-OMe; (2R,4R)-1-Bzl 2-Me 4-BocNH Pro(2-Me); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 1,2-Pyrrolidinedicarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.