Description

2H-Naphth[1,2-B]-1,4-Oxazine,4-Ethyl-3,4,4A,5,6,10B-Hexahydro-,trans-(-)-(9Ci) is a complex, stereochemically defined heterocyclic compound of significant interest in advanced organic synthesis. Its intricate fused-ring structure makes it a valuable chiral building block and synthetic intermediate for pharmaceutical research and development. This compound is primarily utilized by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries to construct novel molecular architectures with potential biological activity. The specific stereochemistry (trans-(-)-) is critical for applications requiring precise three-dimensional control.

Application

• Pharmaceutical Intermediate: Serves as a key chiral scaffold in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or anti-infective targets.
• Asymmetric Synthesis Building Block: Used in the construction of complex natural products or designed molecules where its rigid, fused oxazine structure introduces specific stereochemistry and functionality.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space for drug discovery programs.
• Ligand and Catalyst Development: Potential precursor for developing novel chiral ligands or organocatalysts used in enantioselective transformations.
• Fine Chemical Synthesis: Intermediate for producing specialty chemicals, agrochemicals, or advanced materials requiring a high degree of structural complexity.

Basic Information

Product Name	2H-Naphth[1,2-B]-1,4-Oxazine,4-Ethyl-3,4,4A,5,6,10B-Hexahydro-,trans-(-)-(9Ci)
CAS No.	785004-00-4
Molecular Formula	C16H21NO
Molecular Weight	243.35 g/mol
Synonyms	trans-(-)-4-Ethyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazine; 4-Ethyl-3,4,4a,5,6,10b-hexahydro-2H-naphth[1,2-b][1,4]oxazine, trans-(-)-; (4aR,10bS)-4-Ethyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazine; (-)-trans-4-Ethyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazine; Naphth[1,2-b]-1,4-oxazine, 4-ethyl-3,4,4a,5,6,10b-hexahydro-, trans-(-)-; 2H-Naphth[1,2-b]-1,4-oxazine, 4-ethyl-3,4,4a,5,6,10b-hexahydro-, trans-(-)- (9CI)
EINECS	Contact for details

Quality Control

Every batch of 2H-Naphth[1,2-B]-1,4-Oxazine,4-Ethyl-3,4,4A,5,6,10B-Hexahydro-,trans-(-)-(9Ci) is produced and analyzed under strict quality management protocols. Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development use. Certificates of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles are available upon request. We support our clients' regulatory needs with comprehensive documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.