Description

4-[3,5-Bis-(Trifluoromethyl)Benzyl]Piperidine Hydrochloride is a high-purity, fluorinated piperidine derivative, a crucial advanced intermediate in modern organic synthesis. Its value lies in its unique chemical structure, which combines a piperidine scaffold with electron-withdrawing trifluoromethyl groups, making it a versatile building block for creating complex molecules with enhanced properties. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly those targeting central nervous system (CNS) disorders and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, especially for central nervous system (CNS) targets, receptor modulators, and enzyme inhibitors.
• Agrochemical Synthesis: Used in the development of advanced crop protection agents, including herbicides, fungicides, and insecticides, where the trifluoromethyl groups enhance biological activity and metabolic stability.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of focused compound libraries.
• Ligand and Catalyst Preparation: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs) due to its piperidine nitrogen and aromatic system.
• Material Science Precursor: Potential use in the synthesis of specialty polymers and advanced materials where fluorine incorporation is desired for specific thermal or chemical resistance properties.

Basic Information

Product Name	4-[3,5-Bis-(Trifluoromethyl)Benzyl]Piperidine Hydrochloride
CAS No.	782504-63-6
Molecular Formula	C15H16ClF6N
Molecular Weight	359.74 g/mol
Synonyms	4-[(3,5-Bis(trifluoromethyl)phenyl)methyl]piperidine hydrochloride; 1-[3,5-Bis(trifluoromethyl)benzyl]piperidin-4-amine hydrochloride (tautomer); 4-(3,5-Bis(trifluoromethyl)benzyl)piperidine HCl; Piperidine, 4-[[3,5-bis(trifluoromethyl)phenyl]methyl]-, hydrochloride (1:1); BTP-HCl; 782504-63-6
EINECS	Contact for details

Quality Control

Our 4-[3,5-Bis-(Trifluoromethyl)Benzyl]Piperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.