Description

D-Isovaline, 4-(Aminooxy)-, Methyl Ester (9Ci) is a specialized non-proteinogenic amino acid derivative, distinguished by its unique aminooxy functional group. This compound matters as a high-value chiral building block and intermediate for the synthesis of complex bioactive molecules, offering precise stereochemical control. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, peptide mimetics, and the development of enzyme inhibitors.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for neurological and metabolic targets.
• Peptidomimetic Chemistry: Used to construct peptide analogs and mimetics where the aminooxy group can act as a bioisostere or a handle for further conjugation.
• Enzyme Inhibitor Design: Employed in the synthesis of potential transition-state analog inhibitors for amino acid-processing enzymes.
• Agrochemical Research: Acts as a building block for developing new crop protection agents and plant growth regulators.
• Bioconjugation & Probe Synthesis: The aminooxy moiety is utilized for site-specific oxime ligation with aldehydes and ketones in bioconjugation strategies and diagnostic probe development.
• Academic & Industrial R&D: A valuable tool for synthetic organic chemists exploring new methodologies and structure-activity relationships (SAR).

Basic Information

Product Name	D-Isovaline, 4-(Aminooxy)-, Methyl Ester (9Ci)
CAS No.	782409-47-6
Molecular Formula	C6H12N2O3
Molecular Weight	160.17 g/mol
Synonyms	(2R)-2-Amino-2-methyl-4-(aminooxy)butanoic acid methyl ester; Methyl (2R)-2-amino-2-methyl-4-(aminooxy)butanoate; D-4-(Aminooxy)isovaline methyl ester; (2R)-2-Amino-4-(aminooxy)-2-methylbutanoic acid methyl ester; 4-(Aminooxy)-D-isovaline methyl ester; Methyl O-amino-D-homoserine (derivative); Aminooxy-D-isovaline methyl ester
EINECS	Contact for details

Quality Control

Our D-Isovaline, 4-(Aminooxy)-, Methyl Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, consider storing under an inert atmosphere such as argon or nitrogen in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (D-Isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.