Description

8-Amino-5-Azaspiro[3.5]Nonane-5-Carboxylic Acid 1,1-Dimethylethyl Ester is a high-value, protected amino acid derivative featuring a unique spirocyclic structure. This compound is a critical pharmaceutical intermediate and building block for medicinal chemistry research, enabling the synthesis of novel bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate constrained, nitrogen-containing scaffolds into their target compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Building Block: Used to introduce a rigid, spirocyclic amine moiety into drug candidates to modulate their potency, selectivity, and pharmacokinetic properties.
• Protease Inhibitor Synthesis: Serves as a core structure in the development of inhibitors for various enzymes.
• Agrochemical Research: Employed in creating novel compounds with potential herbicidal or insecticidal activity.
• Ligand Development: Useful for constructing complex chelating agents and catalysts in asymmetric synthesis.
• Peptidomimetics: Incorporated into peptide analogs to enhance metabolic stability and bioavailability.

Basic Information

Product Name	8-Amino-5-Azaspiro[3.5]Nonane-5-Carboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	778646-91-6
Molecular Formula	C13H24N2O2
Molecular Weight	240.34 g/mol
Synonyms	tert-Butyl 8-amino-5-azaspiro[3.5]nonane-5-carboxylate; 5-Azaspiro[3.5]nonane-5-carboxylic acid, 8-amino-, 1,1-dimethylethyl ester; 8-Amino-5-azaspiro[3.5]nonane-5-carboxylic acid tert-butyl ester; Boc-8-amino-5-azaspiro[3.5]nonane; 5-(tert-Butoxycarbonyl)-5-azaspiro[3.5]nonan-8-amine; 8-Amino-5-Boc-5-azaspiro[3.5]nonane; Spirocyclic Boc-protected amine
EINECS	Contact for details

Quality Control

Our 8-Amino-5-Azaspiro[3.5]Nonane-5-Carboxylic Acid 1,1-Dimethylethyl Ester is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.