Description

5-(tert-Butoxycarbonyl)-5,6-Dihydro-4H-Pyrrolo[3,4-D]Thiazole-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a complex bicyclic heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drugs, including kinase inhibitors and other targeted therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing novel pyrrolothiazole-based heterocyclic libraries for biological screening.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry Development: Employed in scaling up synthetic routes for potential new chemical entities (NCEs) from milligram to kilogram scale.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	5-(tert-Butoxycarbonyl)-5,6-Dihydro-4H-Pyrrolo[3,4-D]Thiazole-2-Carboxylic Acid
CAS No.	774533-81-2
Molecular Formula	C11H14N2O4S
Molecular Weight	270.31 g/mol
Synonyms	5-[(tert-Butoxy)carbonyl]-5,6-dihydro-4H-pyrrolo[3,4-d]thiazole-2-carboxylic acid; 5-(Boc)-5,6-dihydro-4H-pyrrolo[3,4-d]thiazole-2-carboxylic acid; tert-Butyl 2-carboxy-4,6-dihydro-5H-pyrrolo[3,4-d]thiazole-5-carboxylate; Boc-protected pyrrolothiazole carboxylic acid; Pyrrolo[3,4-d]thiazole-2-carboxylic acid, 5,6-dihydro-5-[(1,1-dimethylethoxy)carbonyl]-; 774533-81-2
EINECS	Contact for details

Quality Control

Our production of 5-(tert-Butoxycarbonyl)-5,6-Dihydro-4H-Pyrrolo[3,4-D]Thiazole-2-Carboxylic Acid adheres to stringent quality protocols suitable for pharmaceutical R&D and development-scale manufacturing. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided for every shipment. We support development under quality agreements and can align with cGMP guidelines for advanced projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.