Description

4-[(3-Ethynyl-Phenyl)Amino]-6-(1-Methyl-Piperidin-4-Yloxy)-7-Methoxy-Quinazoline CAS NO 774180-32-4 is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of compounds. This compound is of significant commercial interest due to its role as a key building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is primarily needed by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in oncology and signal transduction pathway research.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel, small-molecule kinase inhibitors for targeted cancer therapies.
• Oncology Research: Used as a reference standard or active scaffold in biochemical and cellular assays to study enzyme inhibition and drug mechanism of action.
• Medicinal Chemistry: Serves as a versatile core structure for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Preclinical Development: Employed in the production of batches for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development pipelines for client companies.
• Academic Research: Utilized in university and institutional labs for fundamental research on tyrosine kinase signaling pathways and drug design.

Basic Information

Product Name	4-[(3-Ethynyl-Phenyl)Amino]-6-(1-Methyl-Piperidin-4-Yloxy)-7-Methoxy-Quinazoline
CAS No.	774180-32-4
Molecular Formula	C23H22N4O2
Molecular Weight	386.45 g/mol
Synonyms	4-[(3-Ethynylphenyl)amino]-6-[(1-methyl-4-piperidinyl)oxy]-7-methoxyquinazoline; BIBW 2992 Intermediate; Afatinib Intermediate; Tovok Intermediate; Giotrif Intermediate; 4-[(3-Ethynyl-Phenyl)Amino]-6-(1-Methyl-Piperidin-4-Yloxy)-7-Methoxy-Quinazoline; 6-(1-Methylpiperidin-4-yloxy)-7-methoxy-4-(3-ethynylphenylamino)quinazoline
EINECS	Contact for details

Quality Control

Our production of 4-[(3-Ethynyl-Phenyl)Amino]-6-(1-Methyl-Piperidin-4-Yloxy)-7-Methoxy-Quinazoline adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for research and development applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.