Description

1,11-Bis(4-((1,4,8,11-Tetraazacyclotetradecan-1-Yl)Methyl)Benzyl)-1,4,8,11-Tetraazacyclotetradecane is a sophisticated macrocyclic polyamine ligand, specifically a bis-functionalized cyclam derivative. This compound is of significant interest for its exceptional metal chelating properties, enabling the formation of highly stable and selective complexes with transition metals. It is primarily utilized by researchers and manufacturers in advanced fields such as radiopharmaceutical development, catalysis, and materials science, where precise molecular control is paramount.

Application

• Radiopharmaceutical Precursor: Acts as a bifunctional chelator for labeling antibodies, peptides, and other biomolecules with diagnostic (e.g., 64Cu, 68Ga) or therapeutic (e.g., 177Lu, 225Ac) radioisotopes for targeted cancer imaging and therapy.
• Catalysis Research: Serves as a robust ligand framework for designing homogeneous catalysts in organic synthesis and polymerization processes.
• Molecular Imaging Probes: Used in the development of contrast agents for Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET).
• Metal Ion Separation & Sensing: Employed in analytical chemistry for the selective extraction, detection, and quantification of specific metal ions from complex mixtures.
• Materials Science: Incorporated into metal-organic frameworks (MOFs), polymers, or surfaces to impart specific chemical functionalities or catalytic activity.
• Bioconjugation & Chemical Biology: Provides a stable platform for attaching metals to biomolecules for studying biological processes and developing new therapeutics.

Basic Information

Product Name	1,11-Bis(4-((1,4,8,11-Tetraazacyclotetradecan-1-Yl)Methyl)Benzyl)-1,4,8,11-Tetraazacyclotetradecane
CAS No.	771464-86-9
Molecular Formula	C42H78N12
Molecular Weight	727.16 g/mol
Synonyms	1,11-Bis[4-[(1,4,8,11-tetraazacyclotetradecan-1-yl)methyl]benzyl]-1,4,8,11-tetraazacyclotetradecane; Bifunctional Cyclam Derivative; p-SCN-Bn-DOTA-tetraamide; DOTA-tetraamide-NCS; 1,4,8,11-Tetraazacyclotetradecane-1,11-diacetic acid tetraamide derivative; Bis(cyclam) ligand; p-NCS-Benzyl-DOTA-tetraamide; Macrocyclic polyamine chelator
EINECS	Contact for details

Quality Control

Our production of this high-purity chelator adheres to stringent quality protocols. Every batch undergoes comprehensive analytical characterization, including HPLC for purity assessment, NMR and MS for structural confirmation, and elemental analysis. We support research and GMP-grade manufacturing needs, and a detailed Certificate of Analysis (COA) is provided with each shipment to ensure traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a desiccated environment to prevent moisture absorption and decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.