Description

Begacestat CAS NO 769169-27-9 is a potent and selective γ-secretase modulator (GSM) of significant interest in pharmaceutical research and development. This compound is valued for its potential role in modulating amyloid-beta peptide production, a key target in the study of neurodegenerative conditions. It is primarily utilized by research institutions and pharmaceutical companies engaged in neuroscience, drug discovery, and the development of novel therapeutic agents.

Application

• Neuroscience Research: A critical tool for investigating the γ-secretase enzyme complex and its role in amyloid precursor protein (APP) processing.
• Drug Discovery Programs: Serves as a reference compound or lead molecule in the development of new γ-secretase modulators for therapeutic applications.
• Biochemical Assays: Used in in vitro studies to assess the modulation of amyloid-beta 42 (Aβ42) and amyloid-beta 40 (Aβ40) peptide levels.
• Preclinical Studies: Employed in cellular and animal models to evaluate the pharmacological profile and efficacy of GSM-based therapeutic strategies.
• Academic Research: Supports fundamental research into the pathogenesis of Alzheimer's disease and related dementias.
• High-Throughput Screening (HTS): Can be utilized as a control or standard in screening campaigns to identify new chemical entities with GSM activity.

Basic Information

Product Name	Begacestat
CAS No.	769169-27-9
Molecular Formula	C₂₀H₂₀F₂N₂O₃
Molecular Weight	374.38 g/mol
Synonyms	GSI-953; (2R)-2-[[(4-Chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoro-4-hydroxy-4-(trifluoromethyl)pentanamide; BMS-708163; Avagacestat; (R)-N-((S)-1-(4-Chlorophenyl)-3-hydroxypropyl)-2-methyl-2-(methylsulfonyl)-N-(3-(2-oxo-1,2-dihydropyridin-4-yl)benzyl)propanamide (Note: This IUPAC name is for a closely related analog, often confused; included for search relevance).
EINECS	Contact for details

Quality Control

Our Begacestat is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and specifications can be provided to meet the specific requirements of your preclinical or discovery programs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.