Description

7-Azabicyclo[2.2.1]Heptane-1-Carboxylicacid,3-Hydroxy-,(1S,3S,4R)-(9Ci) is a high-purity, stereochemically defined bicyclic amino acid derivative. This compound serves as a sophisticated chiral building block and key intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily utilized by pharmaceutical and biotechnology R&D teams for the development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring rigid, three-dimensional scaffolds with defined stereochemistry.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of complex drug candidates, including protease inhibitors and neurological agents.
• Advanced Organic Synthesis: Used as a constrained scaffold to introduce the 7-azabicyclo[2.2.1]heptane core into target molecules, influencing their conformational and binding properties.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new chemical space and optimize drug-like properties.
• Asymmetric Catalysis Ligand Precursor: Potential starting material for the development of novel chiral ligands and catalysts.
• Bioconjugation & Peptidomimetics: Useful for creating conformationally restricted peptide analogs (peptidomimetics) to enhance stability and biological activity.
• Academic & Industrial R&D: Serves as a valuable reagent for exploratory chemistry in academic institutions and corporate research laboratories.

Basic Information

Item	Details
Product Name	7-Azabicyclo[2.2.1]Heptane-1-Carboxylicacid,3-Hydroxy-,(1S,3S,4R)-(9Ci)
CAS No.	767616-64-8
Molecular Formula	C7H11NO3
Molecular Weight	157.17 g/mol
Synonyms	(1S,3S,4R)-3-Hydroxy-7-azabicyclo[2.2.1]heptane-1-carboxylic acid; (1S,3S,4R)-3-Hydroxy-1-azoniabicyclo[2.2.1]heptane-1-carboxylate; endo-(1S,4R)-3-Hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylic acid (stereoisomer); 7-Azanorbornane-1-carboxylic acid, 3-hydroxy-, (1S,3S,4R)-; Chiral 7-azabicyclo[2.2.1]heptane derivative
EINECS	Contact for details

Quality Control

Our 7-Azabicyclo[2.2.1]Heptane-1-Carboxylicacid,3-Hydroxy-,(1S,3S,4R)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.