Description

6,7-Dimethoxy-n-(4-Nitrophenyl)Quinazolin-4-Amine is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of heterocyclic compounds. This compound is of significant commercial interest for its role as a key building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is primarily required by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in oncology and anti-inflammatory drug discovery programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel quinazoline-based drug candidates.
• Kinase Inhibitor Research: Serves as a core scaffold for developing potent and selective inhibitors targeting EGFR, VEGFR, and other tyrosine kinases.
• Anticancer Agent Development: Used in medicinal chemistry programs focused on creating small molecule therapies for various cancers.
• Biochemical Tool Compound: Employed in vitro and in vivo studies to investigate cellular signaling pathways and validate drug targets.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.

Basic Information

Product Name	6,7-Dimethoxy-n-(4-Nitrophenyl)Quinazolin-4-Amine
CAS No.	765899-28-3
Molecular Formula	C₁₆H₁₄N₄O₄
Molecular Weight	326.31 g/mol
Synonyms	4-[(4-Nitrophenyl)amino]-6,7-dimethoxyquinazoline; 6,7-Dimethoxy-N-(4-nitrophenyl)quinazolin-4-amine; N-(4-Nitrophenyl)-6,7-dimethoxyquinazolin-4-amine; 6,7-Dimethoxy-4-[(4-nitrophenyl)amino]quinazoline; Quinazolin-4-amine, 6,7-dimethoxy-N-(4-nitrophenyl)-; 765899-28-3
EINECS	Contact for details

Quality Control

Our 6,7-Dimethoxy-n-(4-Nitrophenyl)Quinazolin-4-Amine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container sealed in a dry, inert atmosphere to ensure long-term stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.