Description

7-Trifluoromethyl-1,2,3,4-Tetrahydro-[2,6]Naphthyridine is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring a naphthyridine scaffold with a trifluoromethyl group, makes it a critical intermediate for the development of novel bioactive molecules. This compound is primarily sought after by pharmaceutical and agrochemical R&D organizations for constructing complex chemical libraries and lead optimization programs.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in areas like kinase inhibitors, CNS agents, and anti-infectives.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the biological activity-enhancing properties of the trifluoromethyl group.
• Material Science Precursor: Serves as a building block for advanced organic materials, including ligands for catalysis and components for organic electronics.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects and scale-up activities.

Basic Information

Product Name	7-Trifluoromethyl-1,2,3,4-Tetrahydro-[2,6]Naphthyridine
CAS No.	765298-22-4
Molecular Formula	C9H9F3N2
Molecular Weight	202.18 g/mol
Synonyms	7-(Trifluoromethyl)-1,2,3,4-tetrahydro[2,6]naphthyridine; 7-Trifluoromethyl-1,2,3,4-tetrahydro-2,6-naphthyridine; 1,2,3,4-Tetrahydro-7-(trifluoromethyl)-2,6-naphthyridine; 7-Trifluoromethyl-1,2,3,4-tetrahydro[2,6]naphthyridine; 765298-22-4; 7-Trifluoromethyl-THN; TFMT-HN
EINECS	Contact for details

Quality Control

We maintain a strict quality management system to ensure the consistency and purity of our advanced intermediates. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to verify identity and purity against established specifications. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all critical quality attributes. We support our partners with full traceability and documentation to meet the stringent requirements of GMP and ISO 9001 standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.