Description

(R)-tert-Butyl 1-Cyclohexylpyrrolidin-3-Ylcarbamate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters as a key building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. Pharmaceutical R&D and fine chemical manufacturers need this material for constructing complex molecular architectures in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of advanced drug candidates, especially for central nervous system (CNS) and antiviral targets.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereocenters with high enantiomeric purity.
• Peptidomimetic Research: Serves as a constrained proline-like scaffold in the design of peptidomimetics and macrocyclic compounds.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry: Utilized in the scale-up and route development for the commercial manufacturing of chiral APIs.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis and development projects.

Basic Information

Item	Details
Product Name	(R)-tert-Butyl 1-Cyclohexylpyrrolidin-3-Ylcarbamate
CAS No.	762285-78-9
Molecular Formula	C15H28N2O2
Molecular Weight	268.40 g/mol
Synonyms	(R)-1-Cyclohexyl-3-((tert-butoxycarbonyl)amino)pyrrolidine; (R)-N-Boc-1-Cyclohexyl-3-aminopyrrolidine; (R)-tert-Butyl (1-cyclohexylpyrrolidin-3-yl)carbamate; (3R)-1-Cyclohexyl-3-[[(2-methylpropan-2-yl)oxycarbonyl]amino]pyrrolidine; (R)-N-Boc-3-Amino-1-cyclohexylpyrrolidine; (R)-1-Cyclohexyl-3-(Boc-amino)pyrrolidine; (R)-Boc-1-Cyclohexyl-3-aminopyrrolidine
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 1-Cyclohexylpyrrolidin-3-Ylcarbamate is manufactured under strict quality management systems. Products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity compliant with pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.