Description

3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-8-Methyl-[1,2,4]Triazolo[4,3-A]Pyrazine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its fused triazolopyrazine heterocyclic core and trifluoromethyl functional group. This compound is of significant commercial interest for its role in the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, process chemistry teams, and fine chemical manufacturers seeking a reliable and high-quality building block for complex synthesis.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Development & Scale-up: Serves as a critical raw material for process chemistry during the scale-up from laboratory to pilot plant and commercial manufacturing.
• Active Pharmaceutical Ingredient (API) Synthesis: Incorporated into the final synthetic steps for producing target APIs, leveraging its trifluoromethyl group to enhance metabolic stability and bioavailability.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, validation, and quality control testing.

Basic Information

Product Name	3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-8-Methyl-[1,2,4]Triazolo[4,3-A]Pyrazine Hydrochloride
CAS No.	762240-93-7
Molecular Formula	C9H12ClF3N4
Molecular Weight	268.67 g/mol
Synonyms	8-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride; 3-(Trifluoromethyl)-8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine HCl; 762240-93-7; [1,2,4]Triazolo[4,3-a]pyrazine, 5,6,7,8-tetrahydro-8-methyl-3-(trifluoromethyl)-, hydrochloride (1:1); 8-Methyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-8-Methyl-[1,2,4]Triazolo[4,3-A]Pyrazine Hydrochloride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support audits and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.