Description

Pyridine, 1,2,3,6-Tetrahydro-1-[(2S)-2-Pyrrolidinylmethyl]- (9Ci) is a specialized chiral piperidine derivative with a fused pyrrolidine moiety, serving as a critical advanced intermediate in modern organic synthesis. This compound is valued for its structural complexity and stereochemical purity, which are essential for constructing sophisticated pharmacologically active molecules. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and novel chemical entities, particularly within medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug candidates, especially for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new therapeutic scaffolds.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Process Chemistry Development: Serves as a starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Ligand Synthesis: A precursor for creating novel ligands used in catalysis and molecular recognition.
• Academic Research: Utilized in universities and R&D labs for methodological development in heterocyclic and organonitrogen chemistry.

Basic Information

Item	Details
Product Name	Pyridine, 1,2,3,6-Tetrahydro-1-[(2S)-2-Pyrrolidinylmethyl]- (9Ci)
CAS No.	760993-74-6
Molecular Formula	C10H18N2
Molecular Weight	166.27 g/mol
Synonyms	(2S)-1-[(1,2,3,6-Tetrahydropyridin-1-yl)methyl]pyrrolidine; 1-[(2S)-2-Pyrrolidinylmethyl]-1,2,3,6-tetrahydropyridine; (S)-1-((1,2,3,6-Tetrahydropyridin-1-yl)methyl)pyrrolidine; 1,2,3,6-Tetrahydro-1-[(2S)-2-pyrrolidinylmethyl]pyridine; Chiral tetrahydropyridine-pyrrolidine derivative; Advanced pharmaceutical intermediate 760993-74-6
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) are supplied with each shipment, detailing results from advanced chromatographic (HPLC, GC) and spectroscopic (NMR, IR) methods. Our quality commitment aligns with the standards expected for GMP starting materials and advanced research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.