Description

1-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylic Acid, 4-Hydroxy-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic structure. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), offering a versatile scaffold for medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within the central nervous system (CNS) and anti-infective drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• CNS Drug Development: Used in the research and synthesis of potential therapeutics targeting neurological disorders.
• Anti-infective Agent Synthesis: Employed as a building block for developing novel antibiotics or antiviral compounds.
• Process Chemistry & Scale-up: Supports route scouting, optimization, and cGMP manufacturing for clinical trial material and commercial production.
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for exploratory synthetic chemistry.

Basic Information

Product Name	1-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylic Acid, 4-Hydroxy-, 1,1-Dimethylethyl Ester
CAS No.	757239-67-1
Molecular Formula	C13H23NO4
Molecular Weight	257.33 g/mol
Synonyms	tert-Butyl 4-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate; 8-Boc-4-hydroxy-1-oxa-8-azaspiro[4.5]decane; 4-Hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; 1-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 4-hydroxy-, 1,1-dimethylethyl ester; Boc-protected 4-hydroxy-1-oxa-8-azaspiro[4.5]decane; 4-Hydroxyspirocyclic proline derivative; 8-(tert-Butoxycarbonyl)-4-hydroxy-1-oxa-8-azaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our 1-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylic Acid, 4-Hydroxy-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request. We can support development with research-grade through to cGMP-grade material as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.