Description

Phenol, 4-(2-Amino-1-Methylethyl)-, (S)- (9Ci) is a chiral, substituted phenol derivative featuring a primary amine functional group, making it a versatile building block for advanced chemical synthesis. This compound is valued for its role as a key intermediate in the production of high-value, optically active pharmaceuticals and fine chemicals. It is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require enantiomerically pure intermediates for developing active pharmaceutical ingredients (APIs) and other complex molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular drug classes.
• Agrochemical Synthesis: Used in the research and development of chiral herbicides, fungicides, and plant growth regulators where specific stereochemistry is required for biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis, enabling highly selective chemical transformations.
• Fine Chemical Manufacturing: Employed in the production of specialty chemicals, dyes, and advanced materials that benefit from its phenolic and amine functionalities.
• Biochemical Research: Utilized as a reference standard or building block in medicinal chemistry research for structure-activity relationship (SAR) studies.
• Polymer Modification: Acts as a functional monomer or cross-linking agent in the synthesis of specialty polymers with tailored properties.

Basic Information

Product Name	Phenol, 4-(2-Amino-1-Methylethyl)-, (S)- (9Ci)
CAS No.	757153-78-9
Molecular Formula	C9H13NO
Molecular Weight	151.21 g/mol
Synonyms	(S)-4-(2-Amino-1-methylethyl)phenol; (S)-2-(4-Hydroxyphenyl)-1-methylethylamine; (S)-Hordenine; (S)-N,N-Dimethyltyramine (precursor); (S)-p-[2-(Dimethylamino)ethyl]phenol (related); L-(-)-Hordenine; (-)-Hordenine; 4-[ (1S)-2-Amino-1-methylethyl]phenol
EINECS	Contact for details

Quality Control

Our Phenol, 4-(2-Amino-1-Methylethyl)-, (S)- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting customer specifications and industry standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (S-enantiomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.