Description

5-Chloro-6-(Trifluoromethyl)Nicotinic Acid is a high-value, multi-functional heterocyclic building block characterized by its unique combination of a chlorinated pyridine ring and a trifluoromethyl group. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its structure imparts critical properties like metabolic stability and enhanced bioavailability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for electronic materials and liquid crystals.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	5-Chloro-6-(Trifluoromethyl)Nicotinic Acid
CAS No.	749875-05-6
Molecular Formula	C7H3ClF3NO2
Molecular Weight	225.55 g/mol
Synonyms	5-Chloro-6-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 5-chloro-6-(trifluoromethyl)-; 5-Chloro-6-trifluoromethylnicotinic acid; 5-Chloro-6-trifluoromethyl-3-pyridinecarboxylic acid; 749875-05-6; Nicotinic acid, 5-chloro-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-6-(Trifluoromethyl)Nicotinic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.