Description

1,2-Difluoro-4-Methoxymethoxy-Benzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic placement of fluorine atoms and a protected hydroxyl group, enabling precise molecular modifications that are difficult to achieve with other intermediates. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, structurally defined intermediates for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug candidates, particularly those requiring fluorinated aromatic cores to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides where fluorine incorporation enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Material Research: Serves as a precursor for fluorinated aromatic components in electronic display materials and organic light-emitting diodes (OLEDs), contributing to improved performance and stability.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution to introduce difluoromethoxymethoxy-substituted phenyl groups into more complex architectures.
• Fluorine Chemistry Research: A valuable substrate for studying the effects of fluorine substitution patterns on chemical reactivity and physical properties in academic and industrial R&D settings.

Basic Information

Product Name	1,2-Difluoro-4-Methoxymethoxy-Benzene
CAS No.	749230-22-6
Molecular Formula	C9H10F2O2
Molecular Weight	188.17 g/mol
Synonyms	1,2-Difluoro-4-(methoxymethoxy)benzene; 4-(Methoxymethoxy)-1,2-difluorobenzene; Benzene, 1,2-difluoro-4-(methoxymethoxy)-; 2,3-Difluoro-1-(methoxymethoxy)benzene; 1-(Methoxymethoxy)-2,3-difluorobenzene; Difluoromethoxymethoxybenzene; DFMMB (abbreviation)
EINECS	Contact for details

Quality Control

Our 1,2-Difluoro-4-Methoxymethoxy-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay (by GC/HPLC), impurity profiles, and physical properties. Our quality commitment supports applications requiring high standards, including cGMP for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.