Description

1H-Benzimidazole-5-Carboxylic Acid, 4,5,6,7-Tetrahydro-, (+)- (9Ci) is a chiral, tetrahydrobenzimidazole derivative that serves as a sophisticated building block in advanced organic synthesis. This high-purity intermediate is critical for the development of novel pharmaceutical compounds and fine chemicals, offering a defined stereocenter for precise molecular construction. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides where the specific stereochemistry can influence biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, enhancing the efficiency of stereoselective reactions.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.
• Biochemical Research: Utilized as a standard or probe in biochemical studies investigating enzyme inhibition or receptor binding mechanisms.
• Material Science: Potential building block for advanced organic materials and polymers requiring specific molecular architectures.

Basic Information

Product Name	1H-Benzimidazole-5-Carboxylic Acid, 4,5,6,7-Tetrahydro-, (+)- (9Ci)
CAS No.	749184-49-4
Molecular Formula	C8H10N2O2
Molecular Weight	166.18 g/mol
Synonyms	(+)-4,5,6,7-Tetrahydro-1H-benzimidazole-5-carboxylic acid; (5R)-4,5,6,7-Tetrahydro-1H-benzimidazole-5-carboxylic acid; (R)-4,5,6,7-Tetrahydro-1H-benzimidazole-5-carboxylic acid; 1H-Benzimidazole-5-carboxylic acid, 4,5,6,7-tetrahydro-, (5R)-; Tetrahydrobenzimidazole-5-carboxylic acid; Chiral tetrahydrobenzimidazole carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 1H-Benzimidazole-5-Carboxylic Acid, 4,5,6,7-Tetrahydro-, (+)- (9Ci) adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets exacting standards for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.