Description

4-(2,4-Dichlorophenyl)-N,n-Diethyl-3A,4,5,9B-Tetrahydro-3H-Cyclopenta[C]Quinoline-8-Carboxamide is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This cyclopentaquinoline derivative is valued for its precise molecular architecture, which serves as a critical building block in modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially those targeting neurological pathways.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Employed in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) requiring the cyclopentaquinoline pharmacophore.
• Biochemical Research: Serves as a tool compound or reference standard in biochemical assays and pharmacological studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and pharmacological research projects.

Basic Information

Product Name	4-(2,4-Dichlorophenyl)-N,n-Diethyl-3A,4,5,9B-Tetrahydro-3H-Cyclopenta[C]Quinoline-8-Carboxamide
CAS No.	745787-18-2
Molecular Formula	C23H24Cl2N2O
Molecular Weight	415.35 g/mol
Synonyms	4-(2,4-Dichlorophenyl)-N,N-diethyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxamide; 8-Carboxamido-4-(2,4-dichlorophenyl)-N,N-diethyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline; Cyclopenta[c]quinoline-8-carboxamide, 4-(2,4-dichlorophenyl)-N,N-diethyl-3a,4,5,9b-tetrahydro-; CAS 745787-18-2
EINECS	Contact for details

Quality Control

Our 4-(2,4-Dichlorophenyl)-N,n-Diethyl-3A,4,5,9B-Tetrahydro-3H-Cyclopenta[C]Quinoline-8-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.