Description

4,6-Methanocyclopenta[B]Pyran-2(3H)-One,Hexahydro-5-Hydroxy-4A,5-Dimethyl-,(4S,4As,5R,6R,7As)-(9Ci) is a high-purity, stereochemically defined advanced pharmaceutical intermediate (API) with the CAS number 744208-15-9. This compound is valued for its complex polycyclic structure, which serves as a critical chiral building block in the synthesis of novel active pharmaceutical ingredients. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of complex small-molecule therapeutics, particularly in areas requiring high stereochemical fidelity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized in complex multi-step organic syntheses where its defined stereocenters are crucial for constructing molecules with specific biological activity.
• Medicinal Chemistry Research: Serves as a scaffold or precursor in drug discovery programs, particularly for central nervous system (CNS) or anti-infective targets.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Supplied as a high-purity analytical standard for method development, quality control, and regulatory submissions.
• Academic Research: Employed in university and institutional labs for studying novel synthetic methodologies and reaction mechanisms involving complex oxygen heterocycles.

Basic Information

Product Name	4,6-Methanocyclopenta[B]Pyran-2(3H)-One,Hexahydro-5-Hydroxy-4A,5-Dimethyl-,(4S,4As,5R,6R,7As)-(9Ci)
CAS No.	744208-15-9
Molecular Formula	C11H18O3
Molecular Weight	198.26 g/mol
Synonyms	(4S,4aS,5R,6R,7aS)-Hexahydro-5-hydroxy-4a,5-dimethyl-4,6-methanocyclopenta[b]pyran-2(3H)-one; 4,6-Methanocyclopenta[b]pyran-2(3H)-one, hexahydro-5-hydroxy-4a,5-dimethyl-, (4S,4aS,5R,6R,7aS)-; Hexahydro-5-hydroxy-4a,5-dimethyl-4,6-methanocyclopenta[b]pyran-2(3H)-one; (4S,4aS,5R,6R,7aS)-rel-Hexahydro-5-hydroxy-4a,5-dimethyl-4,6-methanocyclopenta[b]pyran-2(3H)-one; SCHEMBL21868227; ZINC000257830511; ACN0012V9H
EINECS	Contact for details

Quality Control

Our 4,6-Methanocyclopenta[B]Pyran-2(3H)-One,Hexahydro-5-Hydroxy-4A,5-Dimethyl-,(4S,4As,5R,6R,7As)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). For long-term storage, consider storage under inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.