Description

4-Chloro-7-Isopropoxy-6-Methoxy-Quinoline-3-Carbonitrile is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs for oncology and other therapeutic areas. The material is supplied with full analytical documentation to support rigorous R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step production of active pharmaceutical ingredients (APIs), especially kinase inhibitors.
• Drug Discovery & Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Chemical Synthesis: Serves as a versatile scaffold for further functionalization to create libraries of quinoline-based compounds for biological screening.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for GMP and non-GMP production campaigns.

Basic Information

Product Name	4-Chloro-7-Isopropoxy-6-Methoxy-Quinoline-3-Carbonitrile
CAS No.	741276-43-7
Molecular Formula	C14H13ClN2O2
Molecular Weight	276.72 g/mol
Synonyms	4-Chloro-7-isopropoxy-6-methoxyquinoline-3-carbonitrile; 7-Isopropoxy-6-methoxy-4-chloroquinoline-3-carbonitrile; 4-Chloro-7-(1-methylethoxy)-6-methoxy-3-quinolinecarbonitrile; Quinoline-3-carbonitrile, 4-chloro-7-(1-methylethoxy)-6-methoxy-; 741276-43-7
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-7-Isopropoxy-6-Methoxy-Quinoline-3-Carbonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data including HPLC purity, identity confirmation by IR and NMR, and residual solvent analysis to meet the exacting standards of pharmaceutical development. A detailed Certificate of Analysis (COA) is supplied with each shipment to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.