Description

tert-Butyl 6-Fluoro-3-Iodo-1H-Indole-1-Carboxylate is a high-value, multi-functional indole derivative serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in providing a protected, reactive scaffold that enables the efficient construction of complex heterocyclic molecules, particularly in pharmaceutical research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise building blocks for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Medicinal Chemistry Building Block: Utilized in structure-activity relationship (SAR) studies and lead optimization due to the versatile reactivity of the iodine and fluorine substituents on the indole core.
• Agrochemical Research: Serves as an intermediate in the development of new generation herbicides, fungicides, and plant growth regulators.
• Material Science: Used in the research and development of organic electronic materials, such as OLEDs and semiconductors, where fluorinated indole structures are of interest.
• Chemical Biology Probe Synthesis: Acts as a starting material for creating labeled compounds or molecular probes used in biochemical and cellular assays.
• Cross-Coupling Reactions: The 3-iodo group makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce diverse aryl or alkynyl groups.

Basic Information

Product Name	tert-Butyl 6-Fluoro-3-Iodo-1H-Indole-1-Carboxylate
CAS No.	741265-04-3
Molecular Formula	C₁₃H₁₃FINO₂
Molecular Weight	361.15 g/mol
Synonyms	1-Boc-6-Fluoro-3-iodoindole; 6-Fluoro-3-iodo-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 6-fluoro-3-iodo-1H-indole-1-carboxylate; 1H-Indole-1-carboxylic acid, 6-fluoro-3-iodo-, 1,1-dimethylethyl ester; 6-Fluoro-3-iodoindole-1-carboxylic acid tert-butyl ester; Boc-6-F-3-I-indole; tert-Butyl 6-fluoro-3-iodoindole-1-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Fluoro-3-Iodo-1H-Indole-1-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) standards for advanced intermediates, ensuring traceability and documentation for regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep away from heat, sparks, and open flame. Due to its light-sensitive and easily oxidized nature, prolonged exposure to air and light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.