Description

[(4-Methoxyphenyl)(Phenylsulfonyl) Methyl]Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfonyl and carbamate-protected amine functional groups. This compound matters for its critical role in the synthesis of complex bioactive molecules, particularly in medicinal chemistry where it serves as a versatile building block for constructing pharmacophores. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for developing new active ingredients and optimizing synthetic routes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory pathways.
• Medicinal Chemistry Research: Used in parallel and combinatorial synthesis for creating focused libraries to explore structure-activity relationships (SAR).
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up synthetic routes from laboratory to pilot plant scale.
• Agrochemical Synthesis: Intermediate for developing new generation pesticides and herbicides, leveraging its sulfone moiety.
• Peptidomimetics & PROTACs: Utilized in the construction of peptide mimics and Proteolysis Targeting Chimeras (PROTACs) due to its carbamate-protecting group and aromatic systems.
• Chemical Biology Probes: Acts as a precursor for labeling reagents and activity-based probes used in target identification and validation studies.

Basic Information

Product Name	[(4-Methoxyphenyl)(Phenylsulfonyl) Methyl]Carbamic Acid tert-Butyl Ester
CAS No.	741259-87-0
Molecular Formula	C19H23NO5S
Molecular Weight	377.46 g/mol
Synonyms	N-[(4-Methoxyphenyl)(phenylsulfonyl)methyl]carbamic acid tert-butyl ester; tert-Butyl N-[(4-methoxyphenyl)(phenylsulfonyl)methyl]carbamate; Boc-APSM; BOC-Amino(4-methoxyphenyl)(phenylsulfonyl)methane; (4-Methoxyphenyl)(phenylsulfonyl)methyl tert-butylcarbamate; Carbamic acid, N-[(4-methoxyphenyl)(phenylsulfonyl)methyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our [(4-Methoxyphenyl)(Phenylsulfonyl) Methyl]Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material is suitable for demanding pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.