Description

(4-Aminophenyl)Dimethylphosphine Oxide is a specialized organophosphorus compound featuring a unique combination of an aromatic amine and a phosphine oxide functional group. This structure makes it a valuable high-purity intermediate for advanced synthesis in pharmaceutical and materials chemistry. It is primarily sought by R&D chemists and process development scientists working on novel drug candidates, ligands for catalysis, and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting neurological or oncological pathways.
• Ligand Precursor: Serves as a starting material for creating sophisticated phosphine-based ligands used in homogeneous catalysis, such as cross-coupling reactions.
• Polymer Modification: Used to incorporate amine and phosphine oxide functionalities into polymer backbones, enhancing properties like flame retardancy, adhesion, or metal coordination.
• Agrochemical Research: Intermediate in the development of new herbicides, insecticides, or plant growth regulators with novel modes of action.
• Coordination Chemistry: Acts as a chelating agent or ligand for various metal ions, useful in creating complexes for catalysis or material science.
• Material Science Research: Employed in the development of advanced materials, including organic semiconductors, metal-organic frameworks (MOFs), or surface modifiers.

Basic Information

Item	Detail
Product Name	(4-Aminophenyl)Dimethylphosphine Oxide
CAS No.	737751-54-1
Molecular Formula	C8H12NOP
Molecular Weight	169.16 g/mol
Synonyms	4-(Dimethylphosphinyl)aniline; p-Aminophenyldimethylphosphine Oxide; NSC 339062; (4-Aminophenyl)dimethylphosphine oxide; Dimethyl(4-aminophenyl)phosphine oxide; 4-Amino-N,N-dimethylbenzenephosphonamide oxide
EINECS	Contact for details

Quality Control

Every batch of (4-Aminophenyl)Dimethylphosphine Oxide is produced and tested under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to ensure it meets the exacting standards required for research and development. Our quality systems are designed to support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C or as specified on the label. This compound is hygroscopic and easily oxidized; prolonged exposure to air, moisture, or light must be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.