Description

trans-2-[2-(4-Iodophenyl)-2-Oxoethyl]Cyclopentane-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its specific cyclopentane carboxylic acid structure bearing a 4-iodophenyl ketone moiety. This compound is of significant value for its role as a key building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel therapeutic agents, where precise chemical architecture is critical.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders or metabolic diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new chemical entities with improved efficacy and pharmacokinetic profiles.
• API (Active Pharmaceutical Ingredient) Development: Employed in the development and scale-up processes for new active pharmaceutical ingredients requiring this specific iodinated ketone scaffold.
• Bioconjugation & Probe Synthesis: The iodine atom provides a handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Sonogashira), useful for creating labeled compounds for biological testing or diagnostic probes.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the global pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for exploratory organic synthesis and the development of new catalytic methodologies involving aryl halides.

Basic Information

Product Name	trans-2-[2-(4-Iodophenyl)-2-Oxoethyl]Cyclopentane-1-Carboxylic Acid
CAS No.	733740-72-2
Molecular Formula	C14H15IO3
Molecular Weight	358.17 g/mol
Synonyms	2-[2-(4-Iodophenyl)-2-oxoethyl]cyclopentane-1-carboxylic acid (trans-); (1R,2S)-rel-2-[2-(4-Iodophenyl)-2-oxoethyl]cyclopentanecarboxylic Acid; trans-2-(2-(4-Iodobenzoyl)ethyl)cyclopentanecarboxylic Acid; 4-Iodophenyl 2-(1-Carboxycyclopent-2-yl)ethyl Ketone; CAS 733740-72-2; 733740-72-2; 2-(2-(4-Iodophenyl)-2-oxoethyl)cyclopentanecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of trans-2-[2-(4-Iodophenyl)-2-Oxoethyl]Cyclopentane-1-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical applications. Each lot undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles. We support compliance with cGMP and ISO 9001 standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled accordingly. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.