Description

3-(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}-3-(4-Trifluoromethyl-Phenyl)-Propanoic Acid is a specialized Fmoc-protected amino acid derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the precise, sequential construction of complex peptides and peptidomimetics under standard solid-phase peptide synthesis (SPPS) conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel drug candidates, and in biochemical research for studying protein-protein interactions.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, sequential assembly of custom peptide sequences.
• Pharmaceutical Intermediate: For the research and development of novel therapeutic peptides and peptidomimetics targeting various diseases.
• Bioconjugation: Used to introduce the 4-(trifluoromethyl)phenylalanine moiety into proteins or other biomolecules for labeling or functional studies.
• Chemical Biology Probes: Synthesis of labeled peptides for use in assays, imaging, or as tools to investigate biological pathways.
• Material Science: Incorporation into specialty polymers or surfaces to impart specific chemical or biological properties.

Basic Information

Product Name	3-(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}-3-(4-Trifluoromethyl-Phenyl)-Propanoic Acid
CAS No.	728919-94-6
Molecular Formula	C25H20F3NO4
Molecular Weight	455.43 g/mol
Synonyms	Fmoc-4-(trifluoromethyl)-Phe-OH; Fmoc-4-CF3-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(4-trifluoromethylphenyl)-L-alanine; Fmoc-4-(Trifluoromethyl)phenylalanine; N-α-Fmoc-4-(trifluoromethyl)-L-phenylalanine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propanoic acid; Fmoc-Tfm-Phe-OH
EINECS	Contact for details

Quality Control

Our 3-(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}-3-(4-Trifluoromethyl-Phenyl)-Propanoic Acid is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and specification compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.