Description

4-Bromo-3-Chloro-6-Fluoroquinoline is a high-purity, multi-halogenated quinoline derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it a versatile and valuable intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce specific halogen functionalities for bioactivity or material properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel fluoroquinolone antibiotics and other therapeutic agents targeting bacterial infections.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, where the halogenated quinoline core contributes to biological activity.
• Material Science Research: Serves as a building block for creating organic semiconductors, liquid crystals, and fluorescent dyes due to its electron-deficient aromatic system.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying enzyme function and cellular processes.
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig cross-coupling reactions to create complex biaryl structures.
• Functional Group Transformation: Acts as a starting material for further selective functionalization, such as nucleophilic aromatic substitution of the fluorine atom.

Basic Information

Product Name	4-Bromo-3-Chloro-6-Fluoroquinoline
CAS No.	724787-81-9
Molecular Formula	C9H4BrClFN
Molecular Weight	260.49 g/mol
Synonyms	4-Bromo-3-chloro-6-fluoroquinoline; 6-Fluoro-4-bromo-3-chloroquinoline; 3-Chloro-4-bromo-6-fluoroquinoline; Quinoline, 4-bromo-3-chloro-6-fluoro-; 724787-81-9; 4-Br-3-Cl-6-F-quinoline
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Chloro-6-Fluoroquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC-MS for impurity profiling, to ensure it meets the high standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.