Description

7-Bromo-4-Chloro-3-Nitroquinoline is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters because it serves as a critical intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. Research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors need this precise chemical scaffold to introduce specific bromo, chloro, and nitro functionalities into target molecules, enabling the exploration of new chemical spaces and properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinoline-based drug candidates, including potential kinase inhibitors, antimicrobials, and anticancer agents.
• Agrochemical Research: Used in developing new generations of herbicides, fungicides, and insecticides where the quinoline core provides specific biological activity.
• Material Science: Serves as a building block for creating organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient aromatic system.
• Dye & Pigment Synthesis: Employed in the production of specialized dyes and pigments where the nitro and halogen substituents modify color and lightfastness properties.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create more complex biaryl structures.
• Nucleophilic Aromatic Substitution: The chloro and nitro groups activate the ring for substitution reactions, allowing for further functionalization.

Basic Information

Product Name	7-Bromo-4-Chloro-3-Nitroquinoline
CAS No.	723280-98-6
Molecular Formula	C9H4BrClN2O2
Molecular Weight	287.50 g/mol
Synonyms	4-Chloro-7-bromo-3-nitroquinoline; 3-Nitro-7-bromo-4-chloroquinoline; 7-Bromo-4-chloro-3-nitro-quinoline; Quinoline, 7-bromo-4-chloro-3-nitro-; BRN 12423038
EINECS	Contact for details

Quality Control

Our 7-Bromo-4-Chloro-3-Nitroquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent lot-to-lot performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.