Description

4-Fluoro-2-Nitrophenyl Triflate, also known as 5-Fluoro-2-{[(Trifluoromethyl)Sulphonyl]Oxy}Nitrobenzene, is a high-value, multi-functional triflate ester building block designed for advanced organic synthesis. Its core value lies in providing a highly reactive leaving group, enabling efficient and selective cross-coupling reactions and nucleophilic substitutions that are critical for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it serves as a key intermediate in the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of fluorinated drug candidates, particularly in creating complex aryl-aryl bonds via Suzuki, Stille, or Buchwald-Hartwig cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate fluorinated aromatic systems for enhanced bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for synthesizing fluorinated organic semiconductors, liquid crystals, and polymers with tailored electronic and optical properties.
• Chemical Biology & Probe Development: Employed in the creation of fluorinated molecular probes and tags for studying biological mechanisms and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A key reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D pipelines.

Basic Information

Product Name	4-Fluoro-2-Nitrophenyl Triflate
CAS No.	722536-28-9
Molecular Formula	C7H3F4NO5S
Molecular Weight	289.16 g/mol
Synonyms	5-Fluoro-2-{[(Trifluoromethyl)Sulphonyl]Oxy}Nitrobenzene; 2-Nitro-4-fluorophenyl trifluoromethanesulfonate; 4-Fluoro-2-nitrophenyl trifluoromethanesulfonate; 1-Fluoro-4-nitro-2-(trifluoromethanesulfonyloxy)benzene; 4-Fluoro-2-nitro-1-[(trifluoromethyl)sulfonyloxy]benzene; 4-Fluoro-2-nitrophenyl Triflate; 5-Fluoro-2-nitrophenyl Triflate
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Nitrophenyl Triflate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality ensures reliable performance in your most demanding synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.