Description

tert-Butyl 6-Cyano-7-Oxo-4-Azaspiro[2.4]heptane-4-carboxylate is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and cyano-substituted lactam structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of novel protease inhibitors and other therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in cutting-edge drug discovery and process chemistry.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block for the production of complex drug molecules, especially those targeting viral proteases.
• Protease Inhibitor Development: Used in the research and manufacturing of inhibitors for enzymes like HCV NS3/4A protease and SARS-CoV-2 main protease (Mpro).
• Peptidomimetic Chemistry: Its constrained spirocyclic structure is valuable for creating peptidomimetics to enhance metabolic stability and bioavailability of drug candidates.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Development & Scale-Up: Used by chemical development teams to establish robust, scalable synthetic routes for GMP production.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies with custom synthesis projects.

Basic Information

Product Name	tert-Butyl 6-Cyano-7-Oxo-4-Azaspiro[2.4]heptane-4-Carboxylate
CAS No.	718632-43-0
Molecular Formula	C12H16N2O3
Molecular Weight	236.27 g/mol
Synonyms	4-Azaspiro[2.4]heptane-4-carboxylic acid, 6-cyano-7-oxo-, 1,1-dimethylethyl ester; 1-tert-Butyl 6-cyano-7-oxo-4-azaspiro[2.4]heptane-4-carboxylate; tert-Butyl 6-cyano-7-oxo-4-azaspiro[2.4]heptane-4-carboxylate; 718632-43-0; 4-azaspiro[2.4]heptane-4-carboxylic acid, 6-cyano-7-oxo-, tert-butyl ester; Boc-protected 6-cyano-7-oxo-4-azaspiro[2.4]heptane
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Cyano-7-Oxo-4-Azaspiro[2.4]heptane-4-carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.