Description

5,9-Methano-1H-Benzocycloheptene-1,9(2H)-Diol,Octahydro-,(1R,4Ar,5S,9S,9As)-Rel-(9Ci) CAS NO 716380-77-7 is a high-purity, stereochemically defined organic compound belonging to the class of complex polycyclic diols. This compound serves as a critical chiral intermediate or building block in advanced organic synthesis, particularly for the development of novel active pharmaceutical ingredients (APIs) and specialty fine chemicals. It is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the synthesis of complex molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Asymmetric Synthesis: Utilized as a precursor or auxiliary in stereoselective chemical reactions to introduce specific molecular architecture.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fine Chemical Production: Intermediate in the multi-step synthesis of high-value, complex specialty chemicals and advanced materials.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	5,9-Methano-1H-Benzocycloheptene-1,9(2H)-Diol,Octahydro-,(1R,4Ar,5S,9S,9As)-Rel-(9Ci)
CAS No.	716380-77-7
Molecular Formula	C14H22O2
Molecular Weight	222.33 g/mol
Synonyms	(1R,4aR,5S,9S,9aS)-Octahydro-1,9-dihydroxy-5,9-methano-1H-benzocycloheptene; rel-(1R,4aR,5S,9S,9aS)-Octahydro-1,9-dihydroxy-5,9-methano-1H-benzocycloheptene; 716380-77-7; Octahydro-1,9-dihydroxy-5,9-methano-1H-benzocycloheptene, (1R,4aR,5S,9S,9aS)-rel-; Polycyclic Diol Intermediate; Chiral Benzocycloheptene Diol.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP compliance for pharmaceutical applications, with documentation tailored to meet rigorous audit standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or inert gas when appropriate to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.