Description

2H-Indeno[1,2-B]Furan,2-Ethoxy-3,3A,4,8B-Tetrahydro-3A-Methyl-,(2R,3As,8Br)-Rel-(9Ci) is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is valued for its complex, fused-ring structure which serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in areas requiring sophisticated chiral chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and anti-inflammatory targets.
• Organic Synthesis Building Block: Used in complex multi-step organic syntheses to construct intricate polycyclic frameworks found in natural products and specialty chemicals.
• Asymmetric Catalysis Research: Serves as a substrate or ligand precursor in studies exploring new asymmetric catalytic reactions due to its defined stereocenters.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the biological activity and pharmacokinetic properties of lead compounds.
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes for the cost-effective production of target molecules in pilot and commercial scales.

Basic Information

Product Name	2H-Indeno[1,2-B]Furan,2-Ethoxy-3,3A,4,8B-Tetrahydro-3A-Methyl-,(2R,3As,8Br)-Rel-(9Ci)
CAS No.	716367-76-9
Molecular Formula	C14H18O2
Molecular Weight	218.29 g/mol
Synonyms	(2R,3aS,8bR)-2-Ethoxy-3a-methyl-2,3,3a,4,8,8b-hexahydro-1H-indeno[1,2-b]furan; rel-(2R,3aS,8bR)-2-Ethoxy-3a-methyl-2,3,3a,4,8,8b-hexahydro-1H-indeno[1,2-b]furan; 2-Ethoxy-3a-methyl-2,3,3a,4,8,8b-hexahydro-1H-indeno[1,2-b]furan (rel-(2R,3aS,8bR)-form); 1H-Indeno[1,2-b]furan, 2-ethoxy-2,3,3a,4,8,8b-hexahydro-3a-methyl-, (2R,3aS,8bR)-rel-; 716367-76-9; Advanced Indenofuran Intermediate; Chiral Ethoxy Indenofuran Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Quality is verified through comprehensive analytical techniques including HPLC, GC, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, chiral purity, and impurity profiles. We support compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.