Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-7-[4-[[(4-Fluorophenyl)Amino]Thioxomethyl]-3-Methyl-1-Piperazinyl]-1,4-Dihydro-8-Methoxy-4-Oxo- is a high-purity, advanced pharmaceutical intermediate of significant importance in modern synthetic chemistry. Its complex molecular architecture makes it a critical building block for the development of novel active pharmaceutical ingredients (APIs), particularly in the fluoroquinolone antibiotic class. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis and scale-up of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel fluoroquinolone antibiotics, targeting resistant bacterial strains.
• Antibacterial API Development: Serves as a core scaffold for research and development of new antibacterial agents with improved efficacy and safety profiles.
• Process Chemistry & Scale-Up: Used in process optimization and kilogram-to-ton scale manufacturing for clinical trial material and commercial API production.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical innovators with custom synthesis and intermediate supply.
• Academic & Institutional Research: Utilized in medicinal chemistry programs to study structure-activity relationships (SAR) and develop new chemical entities.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-7-[4-[[(4-Fluorophenyl)Amino]Thioxomethyl]-3-Methyl-1-Piperazinyl]-1,4-Dihydro-8-Methoxy-4-Oxo-
CAS No.	714291-18-6
Molecular Formula	C24H23F2N4O3S
Molecular Weight	485.53 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-7-[4-[[(4-fluorophenyl)amino]thioxomethyl]-3-methyl-1-piperazinyl]-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid; Garenoxacin Intermediate; Garenoxacin Carboxylic Acid Derivative; 3-Quinolinecarboxylic acid, 1,4-dihydro-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-[4-[[(4-fluorophenyl)amino]thioxomethyl]-3-methyl-1-piperazinyl]-; AM-1155 Intermediate; OPC-17116 Intermediate; BMS-284756 Synthetic Intermediate
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) that detail all test results against agreed specifications, supporting cGMP compliance for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be light-sensitive and hygroscopic; therefore, containers should be kept sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.