Description

(R)-(+)-2-Acetoxysuccinic Anhydride is a high-purity chiral building block and a key intermediate in organic synthesis. Its value lies in its ability to introduce a protected chiral succinate moiety, enabling the stereoselective construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiomerically pure drugs, especially those targeting cardiovascular and central nervous system disorders.
• Asymmetric Synthesis: Used as a starting material or reagent in catalytic asymmetric reactions to construct molecules with high optical purity.
• Peptide Mimetics & Prodrug Development: Serves as a protected dicarboxylic acid derivative for creating peptide analogs and designing prodrugs with improved bioavailability.
• Ligand & Catalyst Preparation: Employed in the synthesis of chiral ligands and organocatalysts for use in stereoselective transformations.
• Fine Chemical Production: A versatile intermediate for manufacturing specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & R&D: A valuable tool in research laboratories for methodological development in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	(R)-(+)-2-Acetoxysuccinic Anhydride
CAS No.	79814-40-7
Molecular Formula	C6H6O6
Molecular Weight	174.11 g/mol
Synonyms	(R)-2-Acetoxysuccinic Anhydride; (R)-(+)-2-Acetoxybutanedioic Anhydride; (3R)-2,5-Dioxotetrahydrofuran-3-yl Acetate; D-(+)-2-Acetoxysuccinic Anhydride; (R)-Acetoxysuccinic Anhydride; (R)-O-Acetylsuccinic Anhydride; (R)-Malic Acid Acetate Anhydride
EINECS	Contact for details

Quality Control

Our (R)-(+)-2-Acetoxysuccinic Anhydride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.