Description

Trimethoprim Sulfamethizole is a potent combination antibacterial agent, specifically formulated as a co-trimoxazole derivative. This compound is critical for its synergistic action, effectively inhibiting sequential steps in bacterial folate synthesis to combat a broad spectrum of infections. It is primarily required by pharmaceutical manufacturers and research institutions for the development and production of advanced antibacterial formulations and reference standards.

Application

• Pharmaceutical Intermediates: Serves as a key active pharmaceutical ingredient (API) or precursor in the synthesis of combination antibacterial drugs.
• Veterinary Medicine: Used in the formulation of treatments for bacterial infections in livestock and companion animals.
• Microbiological Research: Employed as a standard or reagent in studies of bacterial resistance mechanisms and folate pathway inhibition.
• Clinical Diagnostics: Utilized in laboratory settings for susceptibility testing and as a component in culture media for selective bacterial growth.
• Reference Standard: Supplied as a high-purity material for quality control and analytical method validation in regulatory and QC laboratories.

Basic Information

Product Name	Trimethoprim Sulfamethizole
CAS No.	79735-35-6
Molecular Formula	C14H18N4O3 • C9H10N4O2S2
Molecular Weight	290.32 (Trimethoprim) + 270.33 (Sulfamethizole) = 560.65 g/mol (Combined Molar Mass)
Synonyms	Co-trimoxazole Sulfamethizole; Trimethoprim and Sulfamethizole Combination; Sulfamethizole Trimethoprim Salt; 5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4-pyrimidinediamine compound with 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide; Bactrim component; Septra component; Sulfatrim component; TMP-SMT
EINECS	Contact for details

Quality Control

Our Trimethoprim Sulfamethizole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and related substances, to ensure it meets high-purity standards suitable for pharmaceutical applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.