Description

Echinocandin B is a potent, naturally occurring lipopeptide antifungal agent that serves as the crucial pharmacophore for the semisynthetic production of clinically important echinocandin-class drugs. Its core value lies in its unique mechanism of action, non-competitively inhibiting the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall, which offers a targeted therapeutic approach with reduced host toxicity. This makes it an indispensable key intermediate for pharmaceutical manufacturers and research institutions developing next-generation antifungal therapies targeting invasive candidiasis and aspergillosis.

Application

• Pharmaceutical Intermediate: Primary use as the foundational building block for the semisynthetic manufacture of advanced echinocandin antifungals such as Caspofungin, Micafungin, and Anidulafungin.
• Antifungal Drug Research: Serves as a critical reference standard and starting material in R&D for novel antifungal agents with improved efficacy and safety profiles.
• Biochemical Research: Used in studies investigating fungal cell wall biosynthesis, mechanism of action of glucan synthase inhibitors, and fungal pathogenicity.
• Quality Control & Analytical Standards: Employed as a high-purity certified reference material (CRM) in analytical laboratories for method development, validation, and assay of finished drug products.

Basic Information

Product Name	Echinocandin B
CAS No.	79411-15-7
Molecular Formula	C52H81N7O16
Molecular Weight	1052.2 g/mol
Synonyms	Echinocandin B; Antibiotic A 32204; A 32204; Pneumocandin B0; (4R,5R)-4,5-Dihydroxy-N2-[(4R,5R,8S,10S,11S,12S,13R)-10,11,12,13-tetrahydroxy-5-[(1S,2S)-1-hydroxy-2-methylpentyl]-2,6-dioxo-13-(3-phenylpropanamido)-1-oxa-2-azacyclotridecan-8-yl]-L-ornithyl-L-threonyl-trans-4-hydroxy-L-proline; L-Threonine, N-[(4R,5R)-4,5-dihydroxy-N2-[(4R,5R,8S,10S,11S,12S,13R)-10,11,12,13-tetrahydroxy-5-[(1S,2S)-1-hydroxy-2-methylpentyl]-2,6-dioxo-13-(3-phenylpropanamido)-1-oxa-2-azacyclotridecan-8-yl]-L-ornithyl]-, (3S)-lactone
EINECS	Contact for details

Quality Control

Our Echinocandin B is produced under strict quality management systems to ensure it meets the exacting standards required for pharmaceutical synthesis and research. Each batch undergoes comprehensive analytical testing, including HPLC for purity and related substances, identity confirmation by spectroscopic methods (IR, MS, NMR), and determination of residual solvents. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Related Substances (HPLC)	Individual impurity: ≤ 1.0% Total impurities: ≤ 2.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.