Description

Rac-3-Bromo-2-Oxo-3-Phenylpropanoic Acid is a versatile brominated keto acid derivative that serves as a critical chiral building block and synthetic intermediate in advanced organic synthesis. Its unique structure, featuring both a reactive α-bromo ketone and a carboxylic acid functional group, makes it invaluable for constructing complex molecular architectures. This compound is primarily utilized by research institutions and pharmaceutical development companies engaged in the creation of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of chiral drugs, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and plant growth regulators, leveraging its reactive halogen for coupling reactions.
• Chiral Auxiliary & Ligand Preparation: Serves as a starting material for synthesizing chiral auxiliaries, catalysts, and ligands used in asymmetric synthesis.
• Peptidomimetic & Protease Inhibitor Research: The α-bromo ketone moiety is instrumental in creating electrophilic "warheads" for covalent protease inhibitors.
• Material Science Monomer: Investigated as a specialty monomer for introducing phenyl and carbonyl functionality into polymers.
• Academic & Process Chemistry: Employed in methodological studies for carbon-carbon bond formation, including Reformatsky-type reactions and nucleophilic substitutions.

Basic Information

Product Name	Rac-3-Bromo-2-Oxo-3-Phenylpropanoic Acid
CAS No.	79173-88-9
Molecular Formula	C9H7BrO3
Molecular Weight	243.06 g/mol
Synonyms	3-Bromo-2-oxo-3-phenylpropanoic acid; DL-3-Bromo-2-oxo-3-phenylpropionic acid; (±)-3-Bromo-2-oxo-3-phenylpropanoic acid; 3-Bromo-3-phenylpyruvic acid; α-Bromobenzoylacetic acid; 2-Oxo-3-bromo-3-phenylpropionic acid; NSC 403914; Bromophenylpyruvic acid
EINECS	Contact for details

Quality Control

Every batch of Rac-3-Bromo-2-Oxo-3-Phenylpropanoic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.