Description

2,3:5,6-Di-o-Isopropylidene-D-Mannofuranose is a protected sugar derivative, specifically a mannofuranose acetonide, that serves as a crucial chiral building block and synthetic intermediate. Its value lies in its ability to provide a rigid, protected framework for the stereoselective construction of complex carbohydrates, nucleosides, and other bioactive molecules. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality starting materials for advanced synthesis.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of antiviral and anticancer nucleoside analogs.
• Carbohydrate Chemistry: Fundamental building block for the preparation of complex oligosaccharides, glycoconjugates, and glycomimetics.
• Asymmetric Synthesis: Used as a chiral auxiliary or template to induce stereoselectivity in organic reactions.
• Agrochemical Research: Intermediate in the development of novel, biologically active compounds with specific stereochemistry.
• Fine Chemical Production: Serves as a starting material for specialty chemicals, flavors, and fragrances requiring defined stereochemistry.
• Academic & R&D: A standard reagent in laboratories focused on synthetic organic chemistry and medicinal chemistry projects.

Basic Information

Product Name	2,3:5,6-Di-o-Isopropylidene-D-Mannofuranose
CAS No.	78964-16-6
Molecular Formula	C12H20O6
Molecular Weight	260.28 g/mol
Synonyms	1,2:5,6-Di-O-Isopropylidene-α-D-mannofuranose; Diacetone Mannose; D-Mannose Diethyl Acetal; 2,3:5,6-Di-O-(1-Methylethylidene)-D-mannofuranose; Di-O-isopropylidene-D-mannofuranose; Diacetone-D-mannose; (3aR,5R,6S,6aR)-5-[(R)-1,2-Dihydroxyethyl]-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-6-methanol
EINECS	Contact for details

Quality Control

Our 2,3:5,6-Di-o-Isopropylidene-D-Mannofuranose is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	-18° to -22° (c=1 in H₂O)
Melting Point	118°C - 122°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.