Description

7-(4-Acetyl-Piperazin-1-Yl)-1-Ethyl-6-Fluoro-4-Oxo-1,4-Dihydro-[1,8]Naphthyridine-3-Carboxylic Acid is a high-purity advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for research and development in the synthesis of novel antibacterial agents, particularly targeting DNA gyrase and topoisomerase IV. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical suppliers engaged in the development of next-generation quinolone and naphthyridine-based antibiotics.

Application

• Key Intermediate for Antibacterial Agents: Serves as a crucial building block in the synthesis of potent fluoroquinolone and naphthyridine-class antibiotics.
• Pharmaceutical R&D: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and the development of new anti-infective drug candidates.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production of active pharmaceutical ingredients (APIs).
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory submissions in drug development pipelines.
• Biochemical Research: Applied in studies investigating bacterial enzyme inhibition mechanisms and resistance patterns.

Basic Information

Product Name	7-(4-Acetyl-Piperazin-1-Yl)-1-Ethyl-6-Fluoro-4-Oxo-1,4-Dihydro-[1,8]Naphthyridine-3-Carboxylic Acid
CAS No.	78903-83-0
Molecular Formula	C₁₇H₁₉FN₄O₄
Molecular Weight	362.36 g/mol
Synonyms	1-Ethyl-6-fluoro-7-(4-acetyl-1-piperazinyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; 7-(4-Acetylpiperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-7-(4-acetyl-1-piperazinyl)-4-oxo-; Trovafloxacin Intermediate; Alatrofloxacin Intermediate
EINECS	Contact for details

Quality Control

Our production of 7-(4-Acetyl-Piperazin-1-Yl)-1-Ethyl-6-Fluoro-4-Oxo-1,4-Dihydro-[1,8]Naphthyridine-3-Carboxylic Acid adheres to stringent quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, generated using validated analytical methods (HPLC, NMR, MS). We maintain traceability and documentation in line with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The material is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.