Description

4-(5-(4-Methoxyphenyl)-3-Isoxazolyl)Benzeneacetic Acid is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate of significant commercial and research interest. Its value lies in its role as a key synthetic precursor for COX-2 selective inhibitors, enabling the development of advanced pharmaceutical compounds. This product is essential for manufacturers and R&D laboratories in the pharmaceutical, fine chemical, and academic research sectors focused on novel analgesic and anti-inflammatory agents.

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of COX-2 inhibitor drugs, such as certain isoxazole-based NSAIDs.
• Fine Chemical Synthesis: Used in multi-step organic synthesis to create complex molecules with targeted biological activity.
• Biochemical Research: Serves as a reference standard or probe in studies investigating inflammation pathways and enzyme inhibition mechanisms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of active pharmaceutical ingredients (APIs).
• Academic & Industrial R&D: Employed in discovery chemistry for developing new therapeutic candidates with improved efficacy and safety profiles.

Basic Information

Product Name	4-(5-(4-Methoxyphenyl)-3-Isoxazolyl)Benzeneacetic Acid
CAS No.	78868-42-5
Molecular Formula	C18H15NO4
Molecular Weight	309.32 g/mol
Synonyms	4-[5-(4-Methoxyphenyl)-1,2-oxazol-3-yl]benzeneacetic Acid; 4-[5-(4-Methoxyphenyl)isoxazol-3-yl]phenylacetic Acid; 3-[4-(Carboxymethyl)phenyl]-5-(4-methoxyphenyl)isoxazole; Valdecoxib Intermediate; SC-65872 Intermediate; COX-2 Inhibitor Intermediate; Isoxazole Acetic Acid Derivative
EINECS	Contact for details

Quality Control

Our 4-(5-(4-Methoxyphenyl)-3-Isoxazolyl)Benzeneacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.