Description

1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-Tetraacetic Acid Tetrahydrochloride Hydrate is a high-purity, functionalized macrocyclic chelating agent, specifically a tetra-substituted cyclam derivative. This compound is critically important for its exceptional ability to form stable, inert complexes with a wide range of metal ions, particularly transition metals and lanthanides. It is an essential intermediate and precursor for researchers and manufacturers in the fields of molecular imaging, radiopharmaceuticals, and advanced materials science.

Application

• Radiopharmaceutical Precursor: Key intermediate for synthesizing bifunctional chelators used in PET (Positron Emission Tomography) and SPECT (Single-Photon Emission Computed Tomography) diagnostic imaging agents, often complexed with isotopes like Gallium-68, Copper-64, or Lutetium-177.
• Contrast Agent Development: Serves as a foundational building block for creating next-generation MRI (Magnetic Resonance Imaging) contrast agents by chelating gadolinium or other paramagnetic ions.
• Therapeutic Radiopharmaceuticals: Used in the development of targeted radionuclide therapy (TRT) agents for oncology, where its stable complexes deliver therapeutic isotopes directly to cancer cells.
• Catalysis Research: Acts as a sophisticated ligand in homogeneous catalysis, enabling highly selective and efficient metal-catalyzed organic transformations.
• Metal Ion Scavenging & Separation: Employed in analytical chemistry and environmental science for the selective extraction, separation, and detection of specific metal ions from complex mixtures.
• Materials Science: Utilized in the synthesis of functionalized surfaces, metal-organic frameworks (MOFs), and nanomaterials where precise metal coordination is required.
• Bioconjugation Chemistry: The carboxylic acid groups provide handles for covalent attachment to biomolecules (antibodies, peptides, proteins), creating targeted diagnostic and therapeutic conjugates.
• Academic & Industrial R&D: A vital research chemical for studying coordination chemistry, developing new chelation platforms, and exploring novel applications in sensing and catalysis.

Basic Information

Product Name	1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-Tetraacetic Acid Tetrahydrochloride Hydrate
CAS No.	78668-42-5
Molecular Formula	C18H34N4O8 • 4HCl • xH2O
Molecular Weight	Anhydrous Free Acid: 458.49 g/mol (Contact for exact hydrate form weight)
Synonyms	1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetic acid tetrahydrochloride hydrate; TETA•4HCl•xH2O; Cyclam-tetraacetic acid tetrahydrochloride; 1,4,8,11-Tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetrahydrochloride hydrate; 1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetic acid hydrochloride hydrate; TETRA; H4teta•4HCl•xH2O
EINECS	Contact for details

Quality Control

Our 1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-Tetraacetic Acid Tetrahydrochloride Hydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) that include data from HPLC, NMR, and elemental analysis. Our quality commitment supports applications requiring high-purity chemical intermediates, including research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 10.0% w/w
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.